helicobacter pylori seropositivity among patients with hyperemesis gravidarum

background:   there are also reports from other parts of the world indicating the presence of significant association of h. pylori infection and hyperemesis gravidarum, a bothersome condition that affects pregnant women.   objective: to test the hypothesis that whether h. pylori infection is associated with hyperemesis gravidarum among iranian h.p carriers.   methods: from november 1999 to february 2001, we enrolled 54 pregnant women with hyperemesis gravidarum and 53 asymptomatic pregnant women (control group) in a prospective study.  using a specific serum igg against h. pylori, the seroprevalence of h. pylori infection was determined in both study and control groups.   results: serologically positive h. pylori infection was detected in 44 (82%) out of 54 patients with hyperemesis gravidarum and 29 (55%) out of 53 asymptomatic pregnant women. the prevalence was significantly (p<0.01) higher in those with hyperemesis gravidarum than those in the control group.  the mean ± sd of the igg titer in the study group (69.7 ± 77.5) was significantly (p<0.01) more than that of the control group (34.5 ± 47.8).   conclusion: h. pylori infection may cause hyperemesis gravidarum .